Lifty and Shifty are normally seen as criminals by the other characters, as they are known to steal from them on a regular basis. On occasion, however, the other characters show friendship towards the two raccoons and vice versa.
They appear in the same episode on several occasions but rarely interact. Their prime interaction is Junk in the Trunk, in which Cuddles unwittingly helps Lifty and Shifty with their scheme until they steal his pet mouse and get him killed. Also, in a rare moment of concern for others, Lifty and Shifty attempt to save him in Claw.
Giggles' only interaction with Lifty and Shifty occurs in Gems the Breaks, in which she and Petunia are tied up while Lifty and Shifty steal their lemonade stand and the profits made from it.
Lifty and Shifty take advantage of Toothy in Junk in the Trunk. He simply acts puzzled after Shifty taps his shoulder, seemingly not suspecting that they would steal his pet tortoise. They also appear at a dinner party together sitting opposite each other in Kringle Feast, implying somewhat of a friendship. Furthermore, they are both awed by his singing in Class Act.
- Main article: Lumpy-Lifty-Shifty Relationship
Due to his low intelligence, Lifty and Shifty steal from Lumpy moreso than they do from any other character. As a result, the three are normally not on good terms with each other. However, they demonstrate a friendship in episodes such as The Wrong Side of the Tracks, Happy Trails Pt. 2: Jumping the Shark, and Doggone It.
Handy is a victim of a few of Lifty and Shifty's heists, as can be seen in Wheelin' and Dealin' and Don't Yank My Chain. However, he is genuinely happy when the duo provides a raft for him and the other characters on the island in Happy Trails Pt. 2: Jumping the Shark and avenges their deaths by killing Flaky.
Lifty and Shifty provide Sniffles and the other islanders with a raft in Happy Trails Pt. 2: Jumping the Shark. However, they also take the magic lamp off him in As You Wish, mocking his loss of arms.
Their closest on screen interaction is in As You Wish when Lifty runs over Cub's body, Shifty can even be seen looking at Cub as they run him over. They were also supposed to eat dinner together in Kringle Feast.
Flaky has interacted with Lifty and Shifty twice.
In Happy Trails Pt. 2: Jumping the Shark they provide a raft for her and the other characters to escape from the island, though this ends when Flaky pops the raft with her quills. They also use her to make fake snow in Class Act, much to her obvious dismay.
Lifty and Shifty take advantage of Nutty's addiction on several occasions.
In Dunce Upon a Time, they trick Nutty into swapping his cow for their magic jelly beans.
In the False Alarm episode, they nearly kill Nutty after dropping a truck full of candy on him, but considering how Nutty ended up at hospital rather than dead, it is possible that they saved Nutty. After Nutty is cured of his addiction, they provide him with a new one in order to gain more of his money. Nutty even chases them down when he needs more video games, killing them in process.
In Swelter Skelter, they kill Nutty (likely by accident) in order to get his ice cream.
- Main article: Lifty-Shifty Relationship
As is to be expected, Lifty and Shifty work together all the time during their heists. However, it is not unusual for them to betray or mock each other.
It's unknown as to whether or not Disco Bear and the duo are truly enemies. In Sea What I Found, Lifty and Shifty steal his submarine and kill him in the process, but Disco Bear doesn't know it's them. He also makes a friendly deal with them in Easy Comb, Easy Go, which is also the last time Disco Bear is seen with them.
Much like everyone else, Lifty and Shifty have taken advantage of Flippy. In Easy For You to Sleigh, the thieving duo break into and rob his home, tying him to a chair as he sleeps. Realizing the situation, Flippy flips out from a flashback of the war and ultimately kills the unwelcome guests. On a more positive note, Lifty and Shifty offers to help Flippy and his friends in Happy Trails Pt. 2: Jumping the Shark.
Lifty and Shifty are clearly not on good terms with Russell, as can be seen in Sea What I Found.
Considering their reputation, it can be assumed that Mime does not like Lifty and Shifty. The kleptomaniac duo steal Mime's (supposedly) imaginary safe in Easy For You to Sleigh.
Lifty and Shifty kidnap Cro-Marmot in Swelter Skelter, so they are naturally not on good terms with him.